WHO Afro’s Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN) convened a strategic workshop with key partners from the Reaching the Last Mile Fund—including the Gates Foundation, CIFF, and the END Fund—to align on its 2026–2030 Strategic Framework. Partners played a pivotal role in shaping ESPEN’s six strategic pillars, endorsing its leadership in country support, access to medicines, data systems, and regional coordination. The meeting reinforced ESPEN’s central role in driving cost-effective, integrated approaches to NTD elimination and emphasized the urgent need to translate strategy into action. A joint plan was initiated to expand ESPEN’s support across more countries and domains, with a shared commitment to sustainability, innovation, and equity.